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Méthodes statistiques de noyau en biologie
lundi 29 janvier 2007

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Many problems in computational biology and chemistry can be formalized as classical statistical problems, e.g., pattern recognition, regression or dimension reduction, with the caveat that the data are often not vectors. Indeed objects such as gene sequences, small molecules, protein 3D structures or phylogenetic trees, to name just a few, have particular structures which contain relevant information for the statistical problem but can hardly be encoded into finite-dimensional vector representations.
Kernel methods are a class of algorithms well suited for such problems. Indeed they extend the applicability of many statistical methods initially designed for vectors to virtually any type of data, without the need for explicit vectorization of the data. The price to pay for this extension to non-vectors is the need to define a positive definite kernel between the objects, formally equivalent to an implicit vectorization of the data. The "art" of kernel design for various objects have witnessed important advances in recent years, resulting in many state-of-the-art algorithms in computational biology and chemistry, as well as many other fields.
The goal of this course is to present the mathematical foundations of kernel methods, as well as the main approaches that have emerged so far in kernel design. The relevance of these methods will be illustrated by several examples in computational biology and chemistry.

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    Jean-Philippe Vert
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Jean-Philippe Vert
ENS / Institut Curie / Mines ParisTech
Chercheur en bio-informatique

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Jean-Philippe Vert est directeur du Centre de bio-informatique à Mines ParisTech et directeur adjoint de l’unité « Cancer et génome : bio-informatique, biostatistiques et épidémiologie d'un système complexe » associant Mines ParisTech, l’Institut Curie et l’INSERM.

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Dernière mise à jour : 04/11/2011